Article
Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy/+ rat.
Human molecular genetics - 1 Apr 1997
Bihoreau M T, Ceccherini I, Browne J, Kränzlin B, Romeo G, Lathrop G M, James M R, Gretz N
Abstract excerpt
The Han:SPRD cy/+ strain develops a form of slowly progressive disease that appears similar in many respects to that seen in the autosomal dominant polycystic kidney disease (ADPKD) in humans. We have performed a total genome scan in an experimental backcross population derived from affected Han:...
Topics
- Animals
- Body Weight
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Crosses, Genetic
- Disease Models, Animal
- Genetic Linkage
- Genotype
- Humans
- Microsatellite Repeats
- Organ Size
- Phenotype
- Polycystic Kidney, Autosomal Dominant
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Rats
- Rats, Mutant Strains
- Rats, Wistar