Article
The diagnosis and prognosis of autosomal dominant polycystic kidney disease.
The New England journal of medicine - 18 Oct 1990
Parfrey P S, Bear J C, Morgan J, Cramer B C, McManamon P J, Gault M H, Churchill D N, Singh M, Hewitt R, Somlo S
Abstract excerpt
BACKGROUND: Autosomal dominant polycystic kidney disease is usually caused by a mutant gene at the PKD1 locus on the short arm of chromosome 16, but in about 4 percent of families with the disorder it is caused by unknown mutations elsewhere in the genome. The natural course of the disease in bot...
Topics
- Adult
- Chromosomes, Human, Pair 16
- Genes, Dominant
- Genetic Linkage
- Genotype
- Humans
- Hypertension
- Kidney Diseases
- Kidney Failure, Chronic
- Middle Aged
- Polycystic Kidney Diseases
- Prognosis
- Sensitivity and Specificity
- Ultrasonography