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Article

Mutational analysis of human BLyS in patients with common variable immunodeficiency.

Journal of clinical immunology - 1 Jul 2006

Losi Claretta Gioia, Salzer Ulrich, Gatta Roberta, Lougaris Vassilios, Cattaneo Gemma, Meini Antonella, Soresina Annarosa, Grimbacher Bodo, Plebani Alessandro

Abstract excerpt

BLyS, a TNF family member, is crucial for B cell proliferation and differentiation by acting through its three receptors, TACI, BCMA and BAFF-R. The knock out model for BLyS is characterized by an immunological phenotype reminiscent of the human phenotype of common variable immunodeficiency (CVID). CVID is characterized by a defective B cell compartment, evidencing the putative importance of BLyS in its...

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PMID: 16838132
DOI: 10.1007/s10875-006-9026-2

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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