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Article

Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase.

The Journal of biological chemistry - 25 Aug 2006

D'Abramo Claudia M, Deval Jérôme, Cameron Craig E, Cellai Luciano, Götte Matthias

Abstract excerpt

The RNA-dependent RNA polymerase of the hepatitis C virus and the bovine viral diarrhea virus(BVDV)is able to initiate RNA synthesis denovo in the absence of a primer. Previous crystallographic data have pointed to the existence of a GTP-specific binding site (G-site) that is located in the vicinity of the active site of the BVDV enzyme. Here we have studied the functional role of the G-site and present evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diarrhea Viruses, Bovine Viral

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Share to Templates, Genetic

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Source

Identifiers

PMID: 16831816
DOI: 10.1074/jbc.M600474200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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