Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The differential catalytic activity of ribosome-inactivating proteins saporin 5 and 6 is due to a single substitution at position 162.

The Biochemical journal - 15 Nov 2006

Ghosh Paroma, Batra Janendra K

Abstract excerpt

Saporin, a type I ribosome-inactivating protein produced by the soapwort plant Saponaria officinalis belongs to a multigene family that encodes its several isoforms. The saporin seed isoform 6 has significantly higher N-glycosidase and cytotoxic activities compared with the seed isoform 5, although the two have identical active sites. In the present study, we have investigated the contribution of non-conservative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Catalytic Domain
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circular Dichroism

Share to Dose-Response Relationship, Drug

Share to Electrophoresis, Polyacrylamide Gel

Share to N-Glycosyl Hydrolases

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 16831127
DOI: 10.1042/BJ20060895
PMCID: PMC1635434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

The differential catalytic activity of ribosome-inactivating proteins saporin 5 and 6 is due to a single substitution at position 162.PMID 16831127Read ↗

Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition.Semantic proximity Read ↗

N-terminal deletion affects catalytic activity of saporin toxin.Semantic proximity Read ↗

Expression and characterisation in E. coli of mutant forms of saporin.Semantic proximity Read ↗

Structural analysis of a type 1 ribosome inactivating protein reveals multiple L‑asparagine‑N‑acetyl‑D‑glucosamine monosaccharide modifications: Implications for cytotoxicity.Semantic proximity Read ↗

Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins.Semantic proximity Read ↗

The human asparaginase enzyme (ASPG) inhibits growth in leukemic cellsSemantic proximity Read ↗

Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome.Semantic proximity Read ↗

Variants of subtilisin BPN' with altered specificity profiles.Semantic proximity Read ↗

Stagonospora avenae secretes multiple enzymes that hydrolyze oat leaf saponins.Semantic proximity Read ↗

Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase.Semantic proximity Read ↗

Using natural variation to investigate the function of individual amino acids in the sucrose-binding box of fructan:fructan 6G-fructosyltransferase (6G-FFT) in product formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.