Article
Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.
Endocrine reviews - 1 Apr 2013
Moeller Hanne B, Rittig Søren, Fenton Robert A
Abstract excerpt
The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a pivotal role in maintaining body water balance. The channel is regulated by the peptide hormone arginine vasopressin (AVP), which exerts its effects through the type 2 vasopressin receptor (AVPR2). Disrupted function or regulation of AQP2 or the AVPR2 results in nephrogenic diabetes insipidus (NDI), a common clinical condition...
Topics
- Animals
- Aquaporin 2
- Arginine Vasopressin
- Diabetes Insipidus, Nephrogenic
- Disease Models, Animal
- Humans
- Mutation
- Rats
- Receptors, Vasopressin