Congenital nephrogenic diabetes insipidus: the current state of affairs.

doi:10.1007/s00467-012-2118-8

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Article

Congenital nephrogenic diabetes insipidus: the current state of affairs.

Pediatric nephrology (Berlin, Germany) - 1 Dec 2012

Wesche Daniel, Deen Peter M T, Knoers Nine V A M

Abstract excerpt

The anti-diuretic hormone arginine vasopressin (AVP) is released from the pituitary upon hypovolemia or hypernatremia, and regulates water reabsorption in the renal collecting duct principal cells. Binding of AVP to the arginine vasopressin receptor type 2 (AVPR2) in the basolateral membrane leads to translocation of aquaporin 2 (AQP2) water channels to the apical membrane of the collecting duct principal cells,...

Topics

Diabetes Insipidus, Nephrogenic
Humans
Mutation

Source

Open in PubMed

Identifiers

PMID: 22427315
DOI: 10.1007/s00467-012-2118-8

Genes

AQP2
AVP
AVPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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