Article
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.
Developmental cell - 1 Jul 2006
Lansbergen Gideon, Grigoriev Ilya, Mimori-Kiyosue Yuko, Ohtsuka Toshihisa, Higa Susumu, Kitajima Isao, Demmers Jeroen, Galjart Niels, Houtsmuller Adriaan B, Grosveld Frank, Akhmanova Anna
Abstract excerpt
CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa cells as well as at the leading edge of motile fibroblasts. LL5beta is required for cortical CLASP...
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