Article
Sarcolemma-specific autoantibodies in canine inflammatory myopathy.
Veterinary immunology and immunopathology - 15 Sept 2006
Hankel Sabine, Shelton G Diane, Engvall Eva
Abstract excerpt
Inflammatory myopathies (IM) are relatively common in dogs with an increased incidence in the Boxer and Newfoundland breeds. Here, we show that a high proportion of affected Boxers and Newfoundlands have circulating autoantibodies against unknown sarcolemma antigens, that are muscle-specific but not species specific. We further show that the autoantigen can be extracted from muscle membranes with non-ionic...
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