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Article

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain <i>via</i> its first hydrophobic domain

5 Jul 2006

Abstract excerpt

Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I; HLA class I in humans) to the cell surface and retains the complex in the GA. We report that these effects are due, at least in part, to the interaction between...

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PMID: 16823848
DOI: 10.1002/ijc.22089

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E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain <i>via</i> its first hydrophobic domainPMID 16823848Read ↗

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