Article
CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia.
Clinical science (London, England : 1979) - 1 Nov 2006
Takata Mutsuko, Inazu Akihiro, Katsuda Shoji, Miwa Kenji, Kawashiri Masa-Aki, Nohara Atsushi, Higashikata Toshinori, Kobayashi Junji, Mabuchi Hiroshi, Yamagishi Masakazu
Abstract excerpt
CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-density lipoprotein)-receptor activity. Recently, the -1337 C>T polymorphism in the CETP gene has been reported in REGRESS (Regression Growth Evaluation Statin Study) to be a...
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