Article
Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer.
Experimental & molecular medicine - 30 Jun 2006
Kang Sokbom, Ju Woong, Kim Jae Weon, Park Noh Hyun, Song Yong Sang, Kim Seung Cheol, Park Sang Yoon, Kang Soon Beom, Lee Hyo Pyo
Abstract excerpt
ERCC1 is a DNA repair gene and has been associated with resistance to DNA damaging agents. In this study we hypothesized that a polymorphism of ERCC1 Asn118Asn (C -> T) might affect the platinum-resistance of epithelial ovarian cancer patients to platinum-taxane chemotherapy administered postoperatively. Using the SNapShot assay, we assessed this polymorphism in ERCC1 in 60 ovarian cancer patients....
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