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Article

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides.

AIDS (London, England) - 12 Jun 2006

Fletcher Patricia S, Elliott Julie, Grivel Jean-Charles, Margolis Leonid, Anton Peter, McGowan Ian, Shattock Robin J

Abstract excerpt

OBJECTIVES: Establishment of an in vitro model to evaluate rectal safety and the efficacy of microbicide candidates. DESIGN: An investigation and characterization of human colorectal explant culture for screening candidate microbicides to prevent rectal transmission of HIV-1 infection. METHODS: Human colorectal explants were cultured at the liquid-air interface on gelfoam rafts. Phenotypic characterization of...

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Identifiers

PMID: 16816551
DOI: 10.1097/01.aids.0000232230.96134.80

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CCR5
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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