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Article

Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicide.

Antimicrobial agents and chemotherapy - 1 May 2012

Harman Sarah, Herrera Carolina, Armanasco Naomi, Nuttall Jeremy, Shattock Robin J

Abstract excerpt

Topical blockade of the gp41 fusogenic protein of HIV-1 is one possible strategy by which microbicides could prevent HIV transmission, working early against infection, by inhibiting viral entry into host cells. In this study, we examined the potential of gp41 fusion inhibitors (FIs) as candidate anti-HIV microbicides. Preclinical evaluation of four FIs, C34, T20, T1249, and L'644, was performed using cellular and...

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Identifiers

PMID: 22330930
DOI: 10.1128/AAC.06108-11
PMCID: PMC3346626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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