[Recent studies on vitamin D metabolizing enzymes].

Abstract excerpt

CYP27A1, CYP27B1, and CYP24A1 are members of the cytochrome P450 superfamily, and key enzymes of vitamin D(3) metabolism. CYP27A1 produced at least seven forms of minor metabolites including 1alpha, 25 (OH) (2)D(3) in addition to the major metabolite 25 (OH) D(3). In contrast, CYP27B1 appears to be a special enzyme to catalyze the hydroxylation at C-1alpha position of 25 (OH) D(3). Mutagenesis studies of CYP27B1...

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