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Article

[Klotho gene and endothelial function].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics - 1 May 2006

Saito Yuichiro, Kurabayashi Masahiko, Nakamura Tetsuya, Nagai Ryozo

Abstract excerpt

The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, skin atrophy). We have demonstrated that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in response to acetylcholine stimulation. Systemic nitric oxide...

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Identifiers

PMID: 16813092
DOI: 10.3143/geriatrics.43.342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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