Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factors driving the aspirin exacerbated respiratory disease phenotype.

American journal of rhinology & allergy - 1 Jan 2000

Steinke John W, Borish Larry

Abstract excerpt

BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is explained in part by overexpression of 5-lipoxygenase and leukotriene C4 synthase (LTC4S), resulting in constitutive overproduction of cysteinyl leukotrienes (CysLTs) and driving the surge in CysLT production that occurs with aspirin ingestion. Similarly, AERD is characterized by the overexpression of CysLT receptors. Increased levels of both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspirin
Share to Cysteine
Share to Eosinophilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-4

Share to Leukotrienes

Share to Mast Cells

Share to Respiratory Tract Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 25590316
DOI: 10.2500/ajra.2015.29.4123
PMCID: PMC4288232

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors driving the aspirin exacerbated respiratory disease phenotype.PMID 25590316Read ↗

Update on recent advances in the management of aspirin exacerbated respiratory disease.Semantic proximity Read ↗

Upper airways in aspirin-exacerbated respiratory disease.Semantic proximity Read ↗

Aspirin-exacerbated respiratory disease: an update.Semantic proximity Read ↗

Aspirin or other nonsteroidal inflammatory agent exacerbated asthma.Semantic proximity Read ↗

Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches.Semantic proximity Read ↗

Efficacy of Biologics in Aspirin Exacerbated Respiratory Disease: A Narrative ReviewSemantic proximity Read ↗

Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease.Semantic proximity Read ↗

Physiopathology and genetics in aspirin-exacerbated respiratory disease.Semantic proximity Read ↗

Clinical Characteristics of Aspirin-Exacerbated Respiratory Disease.Semantic proximity Read ↗

Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease.Semantic proximity Read ↗

Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses. EAACI task force on eicosanoids consensus report in times of COVID-19Semantic proximity Read ↗

Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.