Article
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis.
Pharmaceutical research - 1 Dec 2005
Sakurai Yuji, Motohashi Hideyuki, Ogasawara Ken, Terada Tomohiro, Masuda Satohiro, Katsura Toshiya, Mori Noriko, Matsuura Motokazu, Doi Toshio, Fukatsu Atsushi, Inui Ken-ichi
Abstract excerpt
PURPOSE: Our previous studies showed that the mRNA level of human organic anion transporter (hOAT) 3 in the kidney was correlated with the rate of elimination of an anionic antibiotic cefazolin. However, the correlation coefficient was not so high. In the present study, therefore, we enrolled more patients to examine whether additional factors were responsible for the correlation. METHODS: hOAT mRNA levels in...
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