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Article

Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism.

Journal of virology - 1 Jul 2006

Perabo Luca, Goldnau Daniela, White Kathryn, Endell Jan, Boucas Jorge, Humme Sibille, Work Lorraine M, Janicki Hanna, Hallek Michael, Baker Andrew H, Büning Hildegard

Abstract excerpt

Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates binding of heparan sulfate proteoglycan (HSPG), AAV-2's primary receptor, in some but not all mutants. Using an AAV-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16809332
DOI: 10.1128/JVI.00076-06
PMCID: PMC1489073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16809332-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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