Article
Array-CGH analyses of murine malignant lymphomas: genomic clues to understanding the effects of chronic exposure to low-dose-rate gamma rays on lymphomagenesis.
Radiation research - 1 Jul 2006
Takabatake Takashi, Fujikawa Katsuyoshi, Tanaka Satoshi, Hirouchi Tokuhisa, Nakamura Masako, Nakamura Shingo, Braga-Tanaka Ignacia, Ichinohe Kazuaki, Saitou Mikio, Kakinuma Shizuko, Nishimura Mayumi, Shimada Yoshiya, Oghiso Yoichi, Tanaka Kimio
Abstract excerpt
We previously reported that mice chronically irradiated with low-dose-rate gamma rays had significantly shorter mean life spans than nonirradiated controls. This life shortening appeared to be due primarily to earlier death due to malignant lymphomas in the irradiated groups (Tanaka et al., Radiat. Res. 160, 376-379, 2003). To elucidate the molecular pathogenesis of murine lymphomas after low-dose-rate...
Topics
- Animals
- Chromosome Aberrations
- Chromosome Mapping
- Chromosomes
- Gamma Rays
- Genetic Predisposition to Disease
- In Situ Hybridization
- Lymphoma
- Mice
- Mice, Inbred C57BL
- Neoplasms, Radiation-Induced
- Oligonucleotide Array Sequence Analysis