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Article

Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor.

Journal of neurophysiology - 1 Oct 2006

Sheets Patrick L, Gerner Peter, Wang Chi-Fei, Wang Sho-Ya, Wang Ging Kuo, Cummins Theodore R

Abstract excerpt

The calmodulin (CaM) inhibitor trifluoperazine (TFP) can produce analgesia when given intrathecally to rats; however, the mechanism is not known. We asked whether TFP could modulate the Na(v)1.7 sodium channel, which is highly expressed in the peripheral nervous system and plays an important role...

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Source

Identifiers

PMID: 16807347
DOI: 10.1152/jn.00354.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16807347-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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