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Soluble HLA-G Inhibits Cell Cycle Progression in Human Alloreactive T Lymphocytes

1 Feb 2006

Abstract excerpt

HLA-G is involved in regulating T cell responses. Various mechanisms have been proposed to explain the inhibition of T cell proliferation. In this context, the possible role of HLA-G in cell cycle regulation remains to be explored. Using stably transfected M8 cells expressing the secreted isoform (HLA-G5) of HLA-G, we investigated the role of HLA-G in inducing apoptosis and in controlling the cell cycle of...

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PMID: 16424159
DOI: 10.4049/jimmunol.176.3.1331

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