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Article

A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease.

Journal of the American Society of Nephrology : JASN - 1 Jul 2006

Shannon M Brendan, Patton Bruce L, Harvey Scott J, Miner Jeffrey H

Abstract excerpt

Extracellular matrix abnormalities have been found in both human and animal models of polycystic kidney disease (PKD). A new mouse PKD model has been produced through insertion of a PGKneo cassette in an intron of the gene that encodes laminin alpha5 (Lama5), a major tubular and glomerular baseme...

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Identifiers

PMID: 16790509
DOI: 10.1681/ASN.2005121298
PMCID: PMC1482806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16790509-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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