Article
Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme.
Toxicology - 1 Aug 2006
Billaut-Laden Ingrid, Allorge Delphine, Crunelle-Thibaut Aurélie, Rat Emmanuel, Cauffiez Christelle, Chevalier Dany, Houdret Nicole, Lo-Guidice Jean-Marc, Broly Franck
Abstract excerpt
Rhodanese or thiosulfate sulfurtransferase (TST) is a mitochondrial matrix enzyme that plays roles in cyanide detoxification, the formation of iron-sulfur proteins and the modification of sulfur-containing enzymes. Transsulfuration reaction catalyzed by TST is also involved in H(2)S detoxification. To date, no polymorphism of the human TST gene had been reported. We developed a screening strategy based on a...
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