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Article

How wild-type TP53 is inactivated in undifferentiated-type gastric carcinomas: analyses of intratumoral heterogeneity in deletion and mutation of TP53.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2006

Yoshimura Akinobu, Sugihara Hiroyuki, Ling Zhi-Qiang, Peng Dun-Fa, Mukaisho Ken-ichi, Fujiyama Yoshihide, Hattori Takanori

Abstract excerpt

OBJECTIVE: In undifferentiated-type gastric carcinoma (UGC), inactivation of TP53 is infrequent at early stages and comparable to tubular adenocarcinomas (TUBs) at advanced stages. To clarify how TP53 inactivation relates to histogenesis of UGCs, we examined p53 alterations in multiple samples of individual UGCs. METHODS: We used 27 UGCs including 12 mixed types with minor tubular component (TC) and 16 with a...

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Source

Identifiers

PMID: 16785766
DOI: 10.1159/000093090

Genes

TUB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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