Article
Variable SNP density in aspartyl-protease genes of the malaria parasite Plasmodium falciparum.
Gene - 19 Jul 2006
Barry Alyssa E, Leliwa-Sytek Aleksandra, Man Kitty, Kasper Jacob M, Hartl Daniel L, Day Karen P
Abstract excerpt
An analysis of the diversity of the aspartyl proteases of Plasmodium falciparum, known as plasmepsins (PMs), was completed in view of their possible role as drug targets. DNA sequence polymorphisms were identified in nine pm genes including their non-coding (introns and 5' flanking) sequences. All genes contained at least one single nucleotide polymorphism (SNP). Extensive microsatellite diversity was observed...
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