Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5.

Vaccine - 21 Feb 2012

Tanabe Kazuyuki, Arisue Nobuko, Palacpac Nirianne M Q, Yagi Masanori, Tougan Takahiro, Honma Hajime, Ferreira Marcelo U, Färnert Anna, Björkman Anders, Kaneko Akira, Nakamura Masatoshi, Hirayama Kenji, Mita Toshihiro, Horii Toshihiro

Abstract excerpt

SERA5 is regarded as a promising malaria vaccine candidate of the most virulent human malaria parasite Plasmodium falciparum. SERA5 is a 120 kDa abundantly expressed blood-stage protein containing a papain-like protease. Since substantial polymorphism in blood-stage vaccine candidates may potentially limit their efficacy, it is imperative to fully investigate polymorphism of the SERA5 gene (sera5). In this study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa
Share to Antigens, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asia, Southeastern

Share to DNA, Protozoan

Share to Geography

Share to Plasmodium falciparum

Share to Selection, Genetic

Share to South America

Source

Identifiers

PMID: 22230587
DOI: 10.1016/j.vaccine.2011.12.124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5.PMID 22230587Read ↗

Characteristic features of the SERA multigene family in the malaria parasiteSemantic proximity Read ↗

High polymorphism in Plasmodium vivax merozoite surface protein-5 (MSP5).Semantic proximity Read ↗

Plasmodium vivax: C-terminal diversity in the blood stage SERA genes from Indian field isolates.Semantic proximity Read ↗

Plasmodium vivax: N-terminal diversity in the blood stage SERA genes from Indian isolates.Semantic proximity Read ↗

Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum.Semantic proximity Read ↗

Serine Repeat Antigen (SERA5) Is Predominantly Expressed among the SERA Multigene Family of Plasmodium falciparum, and the Acquired Antibody Titers Correlate with Serum Inhibition of the Parasite GrowthSemantic proximity Read ↗

Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin.Semantic proximity Read ↗

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigensSemantic proximity Read ↗

Polymorphism in the gene encoding the Pfs48/45 antigen of Plasmodium falciparum. XI. Asembo Bay Cohort Project.Semantic proximity Read ↗

Plasmodium malariae structure and genetic diversity in sub-Saharan Africa determined from microsatellite variants and linked SNPs in orthologues of antimalarial resistance genes.Semantic proximity Read ↗

Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte–Binding Protein Homologue-5 in Kalifabougou, MaliSemantic proximity Read ↗

Evidence for a Common Role for the Serine-Type Plasmodium falciparum Serine Repeat Antigen Proteases: Implications for Vaccine and Drug DesignSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.