Article
Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease.
Journal of the neurological sciences - 25 Sept 2006
Swerdlow Russell H, Weaver Bradley, Grawey Amy, Wenger Connie, Freed Eric, Worrall Bradford B
Abstract excerpt
The electron transport chain enzyme complex I may play a role in Parkinson's disease (PD) pathogenesis. Association studies considering whether or not complex I-relevant gene polymorphisms contribute to PD risk are discordant. We evaluated four complex I-relevant gene polymorphisms alternatively reported to associate and not associate with PD (tRNA(Gln) T4336C, ND1 T4216C, ND2 G5460A, and the NDUFV2 exon 2 C182T...
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