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Article

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study.

Pediatric research - 1 Jul 2017

Sasaki Seiko, Limpar Mariko, Sata Fumihiro, Kobayashi Sumitaka, Kishi Reiko

Abstract excerpt

BackgroundCaffeine, 1,3,7-trimethylxanthine, is widely consumed by women of reproductive age. Although caffeine has been proposed to inhibit fetal growth, previous studies on the effects of caffeine on infant birth size have yielded inconsistent findings. This inconsistency may result from failure to account for individual differences in caffeine metabolism related to polymorphisms in the gene for CYP1A2, the...

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PMID: 28355205
DOI: 10.1038/pr.2017.70

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