Article
CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo.
The Journal of investigative dermatology - 1 Sept 2006
de Nadaï Patricia, Chenivesse Cécile, Gilet Jules, Porte Henri, Vorng Han, Chang Ying, Walls Andrew F, Wallaert Benoît, Tonnel André-Bernard, Tsicopoulos Anne, Zerwes Hans-Günter
Abstract excerpt
CCR5 is one of the major inflammatory chemokine receptors with potential therapeutical applications in humans. However, the redundancy of chemokines and their receptors, and the species specificity of chemokine receptor antagonists pose challenges to understanding of the role they play in pharmacological situations. To address this question, we used a humanized severe combined immunodeficient mouse model grafted...
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