Article
Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy.
The Journal of biological chemistry - 30 Mar 2001
Knollmann B C, Blatt S A, Horton K, de Freitas F, Miller T, Bell M, Housmans P R, Weissman N J, Morad M, Potter J D
Abstract excerpt
The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and a high incidence of sudden death, despite causing little or no cardiac hypertrophy. In skinned fibers, I79N increased myofilamental calcium sensitivity (Miller, T., Szczesna, D., Housmans, P. R....
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