Article
Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway.
Acta neuropathologica - 1 Nov 2005
Xie Dan, Zeng Yi Xin, Wang Hai Jun, Tai Lai Shan, Wen Jian Ming, Tao Yu, Ma Ning Fang, Hu Liang, Sham Jonathan S T, Guan Xin Yuan
Abstract excerpt
It is believed that there are two distinct pathological pathways leading to the development of human glioblastomas (GBM) in Caucasian populations. Primary (de novo) GBM most often occurs in older individuals, and is characterized by the overexpression/amplification of epidermal growth factor receptor gene (EGFR), whereas secondary GBM, which progresses from a low-grade astrocytoma, often affects younger...
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