Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>α</i> <sub>1</sub> -Antitrypsin Gene Therapy Modulates Cellular Immunity and Efficiently Prevents Type 1 Diabetes in Nonobese Diabetic Mice

1 Jun 2006

Abstract excerpt

An imbalance of the immune-regulatory pathways plays an important role in the development of type 1 diabetes. Therefore, immunoregulatory and antiinflammatory strategies hold great potential for the prevention of this autoimmune disease. Studies have demonstrated that two serine proteinase inhibitors, alpha1-antitrypsin (AAT) and elafin, act as potent antiinflammatory agents. In the present study, we sought to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Galectins and Cancer Biology
Share to Invertebrate Immune Response Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16776571
DOI: 10.1089/hum.2006.17.625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>α</i> <sub>1</sub> -Antitrypsin Gene Therapy Modulates Cellular Immunity and Efficiently Prevents Type 1 Diabetes in Nonobese Diabetic MicePMID 16776571Read ↗

Prevention of type 1 diabetes by gene therapySemantic proximity Read ↗

Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8 <sup>+</sup> T cell exhaustionSemantic proximity Read ↗

A CD40-targeted peptide controls and reverses type 1 diabetes in NOD miceSemantic proximity Read ↗

Distinct immune responses to transgene products from rAAV1 and rAAV8 vectorsSemantic proximity Read ↗

Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expressionSemantic proximity Read ↗

Human Alpha 1 Antitrypsin Suppresses NF-ĸB Activity and Extends Lifespan in Adult DrosophilaSemantic proximity Read ↗

Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice.Semantic proximity Read ↗

In-Vivo Generation of Antigen-Specific Tregs with AAV8 Suppresses Collagen-Induced Arthritis in DBA1 Mice through IL-10 ProductionSemantic proximity Read ↗

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.Semantic proximity Read ↗

Gene therapy of arthritis with TCR isolated from the inflamed paw.Semantic proximity Read ↗

AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1Semantic proximity Read ↗

Phase I Trial of Intramuscular Injection of a Recombinant Adeno-Associated Virus Serotype 2 <i>α</i> 1-Antitrypsin (AAT) Vector in AAT-Deficient AdultsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.