Article
De novo apparently balanced translocations in man are predominantly paternal in origin and associated with a significant increase in paternal age.
Journal of medical genetics - 1 Feb 2010
Thomas N Simon, Morris Joan K, Baptista Julia, Ng Bee Ling, Crolla John A, Jacobs Patricia A
Abstract excerpt
BACKGROUND: Congenital chromosome abnormalities are relatively common in our species and among structural abnormalities the most common class is balanced reciprocal translocations. Determining the parental origin of de novo balanced translocations may provide insights into how and when they arise. While there is a general paternal bias in the origin of non-recurrent unbalanced rearrangements, there are few data...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.