Article
Trait components provide tools to dissect the genetic susceptibility of migraine.
American journal of human genetics - 1 Jul 2006
Anttila V, Kallela M, Oswell G, Kaunisto M A, Nyholt D R, Hamalainen E, Havanka H, Ilmavirta M, Terwilliger J, Sobel E, Peltonen L, Kaprio J, Farkkila M, Wessman M, Palotie A
Abstract excerpt
The commonly used "end diagnosis" phenotype that is adopted in linkage and association studies of complex traits is likely to represent an oversimplified model of the genetic background of a disease. This is also likely to be the case for common types of migraine, for which no convincingly associated genetic variants have been reported. In headache disorders, most genetic studies have used end diagnoses of the...
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