Article
A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine.
Neurogenetics - 1 May 2005
Lea R A, Nyholt D R, Curtain R P, Ovcaric M, Sciascia R, Bellis C, Macmillan J, Quinlan S, Gibson R A, McCarthy L C, Riley J H, Smithies Y J, Kinrade S, Griffiths L R
Abstract excerpt
Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We performed a genome-wide scan of 92 Australian pedigrees phenotyped for migraine with and without aura and for a more heritable form of "severe" migraine. Multipoint non-parametric linkage analysis revealed suggestive...
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