Article
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Neuron - 16 May 2018
Gormley Padhraig, Kurki Mitja I, Hiekkala Marjo Eveliina, Veerapen Kumar, Häppölä Paavo, Mitchell Adele A, Lal Dennis, Palta Priit, Surakka Ida, Kaunisto Mari Anneli, Hämäläinen Eija, Vepsäläinen Salli, Havanka Hannele, Harno Hanna, Ilmavirta Matti, Nissilä Markku, Säkö Erkki, Sumelahti Marja-Liisa, Liukkonen Jarmo, Sillanpää Matti, Metsähonkala Liisa, Koskinen Seppo, Lehtimäki Terho, Raitakari Olli, Männikkö Minna, Ran Caroline, Belin Andrea Carmine, Jousilahti Pekka, Anttila Verneri, Salomaa Veikko, Artto Ville, Färkkilä Markus, Runz Heiko, Daly Mark J, Neale Benjamin M, Ripatti Samuli, Kallela Mikko, Wessman Maija, Palotie Aarno
Abstract excerpt
Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.