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Article

Competition between glucocorticoid receptor and NFκB for control of the human FasL promoter

1 Jun 2006

Abstract excerpt

Glucocorticoids mediate a variety of biological effects via binding their intracellular receptor. Ligand-bound glucocorticoid receptor (GR) translocates to the nucleus and regulates gene transcription in a DNA binding-dependent or independent manner. The predominant biological effect of glucocorticoids on peripheral T cells is immunosupression via transcriptional repression of genes induced during T cell...

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PMID: 16770006
DOI: 10.1096/fj.05-5457com

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