Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes.

Human immunology - 1 Feb 2003

Nishimura Masataka, Obayashi Hiroshi, Mizuta Ikuko, Hara Hirokazu, Adachi Tetsuo, Ohta Mitsuhiro, Tegoshi Hisataka, Fukui Michiaki, Hasegawa Goji, Shigeta Hirofumi, Kitagawa Yoshihiro, Nakano Koji, Kaji Ryuji, Nakamura Naoto

Abstract excerpt

The human leukocyte antigen (HLA) class III region, located on chromosome 6p21, has been regarded as one of the susceptible loci for type 1 diabetes. Because it contains many genes related to inflammatory and immune responses, including tumor necrosis factor (TNF), lymphotoxin-alpha (LT-alpha), and allograft inflammatory factor 1 (AIF-1) genes, it is unclear which gene within the class III region is responsible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 12

Share to Chromosomes, Human, Pair 6

Share to Lymphotoxin-alpha

Share to Receptors, Tumor Necrosis Factor

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Receptors, Tumor Necrosis Factor, Type II

Source

Identifiers

PMID: 12559634
DOI: 10.1016/s0198-8859(02)00799-1

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes.PMID 12559634Read ↗

Tumor necrosis factor-associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes.Semantic proximity Read ↗

Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese.Semantic proximity Read ↗

Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility.Semantic proximity Read ↗

HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Association of single-nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes.Semantic proximity Read ↗

Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients.Semantic proximity Read ↗

Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.Semantic proximity Read ↗

Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082) (G/A), IL-6(-174) (G/C) and IL-1Ra (VNTR) in Egyptian cases with type 1 diabetes mellitus.Semantic proximity Read ↗

Tumor necrosis factor alpha promoter polymorphism in posttransplantation diabetes mellitus of renal transplant recipients.Semantic proximity Read ↗

TNF-alpha and TGF-beta1 gene polymorphisms and renal allograft rejection in Koreans.Semantic proximity Read ↗

Genetic Association of Interleukin 16 Gene Polymorphisms (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children: A Case-Control Study.Semantic proximity Read ↗

Independent association of tumor necrosis factor polymorphism with type 1 diabetes susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.