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Article

Mutations in CD46, a complement regulatory protein, predispose to atypical HUS.

Trends in molecular medicine - 1 May 2004

Goodship Timothy H J, Liszewski M Kathryn, Kemp Elizabeth J, Richards Anna, Atkinson John P

Abstract excerpt

Membrane cofactor protein (MCP, CD46) is a widely expressed transmembrane complement regulator. As does the soluble regulator factor H, it inhibits complement activation by inactivating the C3b that is deposited on target membranes. Factor H mutations have been described in 15-30% of patients with atypical haemolytic uraemic syndrome (HUS). Recent studies have identified mutations in the MCP gene in four...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15121049
DOI: 10.1016/j.molmed.2004.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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