Article
MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function.
Annals of human genetics - 1 Jul 2006
Rousseau K, Vinall L E, Butterworth S L, Hardy R J, Holloway J, Wadsworth M E J, Swallow D M
Abstract excerpt
The mucin MUC7 is a glycoprotein that plays a role in bacterial clearance and has candidacidal activity. There are two common allelic forms with 5 or 6 tandem repeats (TR) of a 23 amino acid motif within the highly glycosylated (mucin) domain. The MUC7*5 allele has previously been shown to be less prevalent in patients with asthma, suggesting a protective role in respiratory function. Here we report the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.