Article
Genetic regulation of MUC1 alternative splicing in human tissues.
British journal of cancer - 16 Sept 2008
Ng W, Loh A X W, Teixeira A S, Pereira S P, Swallow D M
Abstract excerpt
The membrane mucin MUC1 is aberrantly expressed in a variety of cancers, and in stomach, it is a ligand for Helicobacter pylori where it plays a role in gastric carcinogenesis. Splicing variation, leading to a 9-amino acid insertion in the signal peptide region, was proposed to be because of a single-nucleotide polymorphism (rs4072037) at the 5' end of exon 2, but is also reported to be cancer-associated....
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