Article
Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway.
Gut - 1 Jan 2011
Huang Hsuan-Hao, Shih Wei-Liang, Li Yi-Hsiu, Wu Chih-Feng, Chen Pei-Jer, Lin Chih-Lin, Liu Chun-Jen, Liaw Yun-Fan, Lin Shi-Ming, Lee Shou-Dong, Yu Ming-Whei
Abstract excerpt
OBJECTIVE: High viraemia of hepatitis B virus (HBV) influences all phases in the development of hepatocellular carcinoma (HCC). This study was designed to estimate the overall contribution of host genetics to HBV viraemia, and investigate the influence of common single-nucleotide polymorphisms (SNPs) in the interferon γ (IFNγ) signalling pathway, which is pivotal in the non-cytolytic clearance of HBV. METHODS: We...
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