Article
Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.
Cancer - 15 Jul 2006
Sato Norihiro, Fukushima Noriyoshi, Matsubayashi Hiroyuki, Iacobuzio-Donahue Christine A, Yeo Charles J, Goggins Michael
Abstract excerpt
BACKGROUND: The p53-dependent G2/M checkpoint plays a key role in the maintenance of genomic integrity, thereby protecting cells from neoplastic progression. Reprimo, a gene involved in the p53-induced G2 cell cycle arrest, has been recently identified as a novel target for aberrant methylation in pancreatic and other cancers. The biological and clinical relevance of Reprimo methylation in pancreatic cancer was...
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