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Article

Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media.

The Journal of allergy and clinical immunology - 1 Jun 2006

Wiertsema Selma P, Herpers Bjorn L, Veenhoven Reinier H, Salimans Marcel M M, Ruven Henk J T, Sanders Elisabeth A M, Rijkers Ger T

Abstract excerpt

BACKGROUND: Mannan-binding lectin (MBL) can bind to microorganisms, initiating the lectin pathway of complement activation. Aberrant MBL serum levels, caused by MBL2 gene polymorphisms, are a possible risk factor for recurrent infections. Within the 7 common MBL haplotypes, still considerable variation in MBL serum levels exists. OBJECTIVE: To investigate functional MBL levels and MBL2 polymorphisms in a large...

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Source

Identifiers

PMID: 16750996
DOI: 10.1016/j.jaci.2006.01.031

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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