Association of DNA repair gene polymorphisms with response to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer.

doi:10.1200/JCO.2010.30.5334

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Article

Association of DNA repair gene polymorphisms with response to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2010

Shiraishi Kouya, Kohno Takashi, Tanai Chiharu, Goto Yasushi, Kuchiba Aya, Yamamoto Seiichiro, Tsuta Koji, Nokihara Hiroshi, Yamamoto Noboru, Sekine Ikuo, Ohe Yuichiro, Tamura Tomohide, Yokota Jun, Kunitoh Hideo

Abstract excerpt

PURPOSE: To identify polymorphisms in DNA repair genes that affect responses to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: In total, 640 patients with NSCLC who received platinum-based doublet chemotherapy in the National Cancer Center Hospital in Japan from 2000 to 2008 and whose responses were evaluated by Response Evaluation Criteria in Solid...

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PMID: 20940192
DOI: 10.1200/JCO.2010.30.5334

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