Article
Polymorphism due to variable number of repeats in the human involucrin gene.
Genomics - 1 Apr 1991
Simon M, Phillips M, Green H
Abstract excerpt
The coding region of the involucrin gene in higher primates contains a segment consisting of numerous tandem repeats of a 10-codon sequence. The process of repeat addition began in a common ancestor of all higher primates and subsequent repeats were added vectorially. As a result, the principal site of repeat addition has moved in the 3' to 5' direction and the most recently generated repeats (the late region)...
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