Article
Mutation of the repeat number of the HPRTB locus and structure of rare intermediate alleles.
International journal of legal medicine - 1 Jan 1999
Mertens G, Gielis M, Mommers N, Mularoni A, Lamartine J, Heylen H, Muylle L, Vandenberghe A
Abstract excerpt
During routine paternity testing a mutation of a paternal allele at the HPRTB locus was observed. The opportunity was taken to analyse this mutation at a molecular level. The repeat sequence is flanked by an imperfect repeat sequence and this region could be involved in the mutation mechanism. For this reason, we also examined the structure of "intermediate" alleles. Sequencing confirmed the insertion of a...
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