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Article

Evolution of a hypervariable region of the low density lipoprotein receptor (LDLR) gene in humans and other hominoids.

Genetica - 1 Jun 2004

Kass David H, Knight Alec, Deininger Prescott L

Abstract excerpt

Alu repeats in primates have been shown to evolve at a neutral mutation rate, as anticipated for non-coding autosomal loci. However, we have identified Alu elements within the 3' untranslated region (UTR) of the low density lipoprotein receptor (LDLR) gene that exhibited highly accelerated rates of evolution. In humans, a 100- and 25-fold increase in average divergence, for an upstream Alu (Alu U) and a...

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Source

Identifiers

PMID: 15330118
DOI: 10.1023/b:gene.0000040387.14317.98

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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