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Article

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

15 May 1991

Abstract excerpt

Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of interleukin 2 to induce lymphokine-activated killer cells. We now report the cloning and expression of both human CLMF subunit cDNAs from a lymphoblastoid B-cell line, NC-37. The two...

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PMID: 1674604
DOI: 10.1073/pnas.88.10.4143

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